2ea2: Difference between revisions

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[[Image:2ea2.jpg|left|200px]]<br /><applet load="2ea2" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2ea2.jpg|left|200px]]
caption="2ea2, resolution 2.50&Aring;" />
 
'''h-MetAP2 complexed with A773812'''<br />
{{Structure
|PDB= 2ea2 |SIZE=350|CAPTION= <scene name='initialview01'>2ea2</scene>, resolution 2.50&Aring;
|SITE= <scene name='pdbsite=AC1:Mn+Binding+Site+For+Residue+A+480'>AC1</scene>, <scene name='pdbsite=AC2:Mn+Binding+Site+For+Residue+A+481'>AC2</scene> and <scene name='pdbsite=AC3:F77+Binding+Site+For+Residue+A+482'>AC3</scene>
|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene> and <scene name='pdbligand=F77:'>F77</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18]
|GENE=
}}
 
'''h-MetAP2 complexed with A773812'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2EA2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MN:'>MN</scene> and <scene name='pdbligand=F77:'>F77</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] Known structural/functional Sites: <scene name='pdbsite=AC1:Mn+Binding+Site+For+Residue+A+480'>AC1</scene>, <scene name='pdbsite=AC2:Mn+Binding+Site+For+Residue+A+481'>AC2</scene> and <scene name='pdbsite=AC3:F77+Binding+Site+For+Residue+A+482'>AC3</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EA2 OCA].  
2EA2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EA2 OCA].  


==Reference==
==Reference==
Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids., Wang GT, Mantei RA, Kawai M, Tedrow JS, Barnes DM, Wang J, Zhang Q, Lou P, Garcia LA, Bouska J, Yates M, Park C, Judge RA, Lesniewski R, Sheppard GS, Bell RL, Bioorg Med Chem Lett. 2007 May 15;17(10):2817-22. Epub 2007 Feb 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17350258 17350258]
Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids., Wang GT, Mantei RA, Kawai M, Tedrow JS, Barnes DM, Wang J, Zhang Q, Lou P, Garcia LA, Bouska J, Yates M, Park C, Judge RA, Lesniewski R, Sheppard GS, Bell RL, Bioorg Med Chem Lett. 2007 May 15;17(10):2817-22. Epub 2007 Feb 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17350258 17350258]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Methionyl aminopeptidase]]
[[Category: Methionyl aminopeptidase]]
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[[Category: protein-ligand complex]]
[[Category: protein-ligand complex]]


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