3zon: Difference between revisions
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==Human TYK2 pseudokinase domain bound to a kinase inhibitor== | |||
<StructureSection load='3zon' size='340' side='right' caption='[[3zon]], [[Resolution|resolution]] 2.15Å' scene=''> | |||
== Structural highlights == | |||
==Disease== | <table><tr><td colspan='2'>[[3zon]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZON OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZON FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IK1:5-PHENYL-2-UREIDOTHIOPHENE-3-CARBOXAMIDE'>IK1</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zon FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zon OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zon RCSB], [http://www.ebi.ac.uk/pdbsum/3zon PDBsum]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[http://omim.org/entry/611521 611521]]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE. | [[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[http://omim.org/entry/611521 611521]]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE. | ||
== Function == | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref> | [[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref> | ||
== | ==See Also== | ||
[[ | *[[Janus kinase|Janus kinase]] | ||
== References == | |||
== | <references/> | ||
<references | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Berridge, G | [[Category: Berridge, G]] | ||
[[Category: Bountra, C | [[Category: Bountra, C]] | ||
[[Category: Chalk, R | [[Category: Chalk, R]] | ||
[[Category: Daga, N | [[Category: Daga, N]] | ||
[[Category: Delft, F von | [[Category: Delft, F von]] | ||
[[Category: Edwards, A | [[Category: Edwards, A]] | ||
[[Category: Elkins, J M | [[Category: Elkins, J M]] | ||
[[Category: Knapp, S | [[Category: Knapp, S]] | ||
[[Category: Krojer, T | [[Category: Krojer, T]] | ||
[[Category: Picaud, S | [[Category: Picaud, S]] | ||
[[Category: Salah, E | [[Category: Salah, E]] | ||
[[Category: Savitsky, P | [[Category: Savitsky, P]] | ||
[[Category: Wang, J | [[Category: Wang, J]] | ||
[[Category: Jak]] | [[Category: Jak]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 10:07, 21 December 2014
Human TYK2 pseudokinase domain bound to a kinase inhibitor
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