4ein: Difference between revisions

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~~{{STRUCTURE_4ein| PDB=4ein | SCENE= }}~~

==Crystal structure of mouse thymidylate synthase in binary complex with a substrate analogue and strong inhibitor, N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate==

===Crystal structure of mouse thymidylate synthase in binary complex with a substrate analogue and strong inhibitor, N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate===

== Structural highlights ==

<table><tr><td colspan='2'>[[4ein]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EIN OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EIN FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NOH:2-DEOXY-N-HYDROXYCYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>NOH</scene></td></tr>

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">Tyms ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ein FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ein OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ein RCSB], [http://www.ebi.ac.uk/pdbsum/4ein PDBsum]</td></tr>

</table>

==~~Function~~==

==See Also==

[[~~http://www.uniprot.org/uniprot/TYSY_MOUSE TYSY_MOUSE~~]] ~~Contributes to the de novo mitochondrial thymidylate biosynthesis pathway (By similarity).~~

*[[Thymidylate synthase|Thymidylate synthase]]

__TOC__

~~==About this Structure==~~

</StructureSection>

~~[[4ein]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin~~/~~ocashort?id=4EIN OCA].~~

[[Category: Mus musculus]]

[[Category: Thymidylate synthase]]

[[Category: Dowiercial, A.]]

[[Category: Dowiercial, A]]

[[Category: Jarmula, A.]]

[[Category: Jarmula, A]]

[[Category: Kierdaszuk, B.]]

[[Category: Kierdaszuk, B]]

[[Category: Rode, W.]]

[[Category: Rode, W]]

[[Category: Rypniewski, W R.]]

[[Category: Rypniewski, W R]]

[[Category: Wilk, P.]]

[[Category: Wilk, P]]

[[Category: Binding site]]

[[Category: Catalysis]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_4ein|  PDB=4ein  |  SCENE=  }}
+==Crystal structure of mouse thymidylate synthase in binary complex with a substrate analogue and strong inhibitor, N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate==
-===Crystal structure of mouse thymidylate synthase in binary complex with a substrate analogue and strong inhibitor, N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate===
+<StructureSection load='4ein' size='340' side='right' caption='[[4ein]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ein]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EIN FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NOH:2-DEOXY-N-HYDROXYCYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>NOH</scene></td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tyms ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ein FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ein OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ein RCSB], [http://www.ebi.ac.uk/pdbsum/4ein PDBsum]</span></td></tr>
+</table>
-==Function==
+==See Also==
-[[http://www.uniprot.org/uniprot/TYSY_MOUSE TYSY_MOUSE]] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway (By similarity).
+*[[Thymidylate synthase|Thymidylate synthase]]
+__TOC__
-==About this Structure==
+</StructureSection>
-[[4ein]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EIN OCA].
 [[Category: Mus musculus]]
 [[Category: Thymidylate synthase]]
-[[Category: Dowiercial, A.]]
+[[Category: Dowiercial, A]]
-[[Category: Jarmula, A.]]
+[[Category: Jarmula, A]]
-[[Category: Kierdaszuk, B.]]
+[[Category: Kierdaszuk, B]]
-[[Category: Rode, W.]]
+[[Category: Rode, W]]
-[[Category: Rypniewski, W R.]]
+[[Category: Rypniewski, W R]]
-[[Category: Wilk, P.]]
+[[Category: Wilk, P]]
 [[Category: Binding site]]
 [[Category: Catalysis]]