2eho: Difference between revisions
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[[Image:2eho.jpg|left|200px]] | [[Image:2eho.jpg|left|200px]] | ||
'''Crystal structure of human GINS complex''' | {{Structure | ||
|PDB= 2eho |SIZE=350|CAPTION= <scene name='initialview01'>2eho</scene>, resolution 3.00Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | |||
|ACTIVITY= | |||
|GENE= Psf1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), PSF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), Psf3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |||
}} | |||
'''Crystal structure of human GINS complex''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2EHO is a [ | 2EHO is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EHO OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structure of the human GINS complex., Choi JM, Lim HS, Kim JJ, Song OK, Cho Y, Genes Dev. 2007 Jun 1;21(11):1316-21. PMID:[http:// | Crystal structure of the human GINS complex., Choi JM, Lim HS, Kim JJ, Song OK, Cho Y, Genes Dev. 2007 Jun 1;21(11):1316-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17545466 17545466] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: protein-protein complex]] | [[Category: protein-protein complex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:40:17 2008'' | ||
Revision as of 14:40, 20 March 2008
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| 2eho, resolution 3.00Å | |||||||||||||
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| Ligands: | SO4 | ||||||||||||
| Gene: | Psf1 (Homo sapiens), PSF2 (Homo sapiens), Psf3 (Homo sapiens) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal structure of human GINS complex
Overview
The GINS complex mediates the assembly of the MCM2-7 (minichromosome maintenance) complex with proteins in a replisome progression complex. The eukaryotic GINS complex is composed of Sld5, Psf1, Psf2, and Psf3, which must be assembled for cell proliferation. We determined the crystal structure of the human GINS complex: GINS forms an elliptical shape with a small central channel. The structures of Sld5 and Psf2 resemble those of Psf1 and Psf3, respectively. In addition, the N-terminal and C-terminal domains of Sld5/Psf1 are permuted in Psf2/Psf3, which suggests that the four proteins have evolved from a common ancestor. Using a structure-based mutational analysis, we identified the functionally critical surface regions of the GINS complex.
Disease
Known diseases associated with this structure: Bare lymphocyte syndrome, type I OMIM:[170260], Bare lymphocyte syndrome, type I, due to TAP2 deficiency OMIM:[170261], Wegener-like granulomatosis OMIM:[170261]
About this Structure
2EHO is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the human GINS complex., Choi JM, Lim HS, Kim JJ, Song OK, Cho Y, Genes Dev. 2007 Jun 1;21(11):1316-21. PMID:17545466
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