CEN-101: Difference between revisions
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Until a little over one decade ago, bacteria were thought to act only as independent organisms, in a planktonic state. A bioflim is an aggregate of microbes with a distinct architecture. It is a “microscopic city” in which microbial cells bring nutrients, oxygen and other necessities through fluid filled channels to support life within the biofilm community. Bacteria growing within the biofilm are protected from antibiotic exposure and are up to 1,000 times more resistant than bacteria not growing inside a biofilm | Until a little over one decade ago, bacteria were thought to act only as independent organisms, in a planktonic state. A bioflim is an aggregate of microbes with a distinct architecture. It is a “microscopic city” in which microbial cells bring nutrients, oxygen and other necessities through fluid filled channels to support life within the biofilm community. Bacteria growing within the biofilm are protected from antibiotic exposure and are up to 1,000 times more resistant than bacteria not growing inside a biofilm | ||
<ref name="James">PMID:18086294</ref> | |||
<ref name="Costerton">PMID:10334980</ref>. A growing body of peer reviewed publications supports the approach of attacking biofilm as an effective method to combat staph infections. | |||
It is now well know that staph must have a sufficient population (quorum) to allow them to form biofilms, enabling much improved survival in the host. Molecules involved in quorum sensing (QS) by Staphylococci like S. aureus include RNAIII activating protein (RAP), target of RAP (TRAP) and proteins encoded by the accessory gene regulator locus (agr), which ultimately initiate the expression of a myriad of virulence factors such as proteases, hemolysins and various other toxins [2, 9] | It is now well know that staph must have a sufficient population (quorum) to allow them to form biofilms, enabling much improved survival in the host. Molecules involved in quorum sensing (QS) by Staphylococci like S. aureus include RNAIII activating protein (RAP), target of RAP (TRAP) and proteins encoded by the accessory gene regulator locus (agr), which ultimately initiate the expression of a myriad of virulence factors such as proteases, hemolysins and various other toxins [2, 9] | ||
