CEN-101: Difference between revisions
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<ref name="Costerton">PMID:10334980</ref>. A growing body of peer reviewed publications supports the approach of attacking biofilm as an effective method to combat staph infections. | <ref name="Costerton">PMID:10334980</ref>. A growing body of peer reviewed publications supports the approach of attacking biofilm as an effective method to combat staph infections. | ||
It is now well know that staph must have a sufficient population (quorum) to allow them to form biofilms, enabling much improved survival in the host. Molecules involved in quorum sensing (QS) by Staphylococci like S. aureus include RNAIII activating protein (RAP), target of RAP (TRAP) and proteins encoded by the accessory gene regulator locus (agr), which ultimately initiate the expression of a myriad of virulence factors such as proteases, hemolysins and various other toxins | It is now well know that staph must have a sufficient population (quorum) to allow them to form biofilms, enabling much improved survival in the host. Molecules involved in quorum sensing (QS) by Staphylococci like S. aureus include RNAIII activating protein (RAP), target of RAP (TRAP) and proteins encoded by the accessory gene regulator locus (agr), which ultimately initiate the expression of a myriad of virulence factors such as proteases, hemolysins and various other toxins [2, 9] | ||
=The Solution= | =The Solution= | ||
