Sandbox Reserved 598: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 21: | Line 21: | ||
==The Function of Jak2 == | ==The Function of Jak2 == | ||
There are four members of the janus kinase family, Jak1, Jak2, Jak3, and Jak4. Each kinase has unique functions based on their respective abilities to bind to different cytokine receptors. Out of those four janus kinases, Jak2 is responsible for erythropoietin and thrombopoietin signaling which then causes the proliferation, activation and transcription of blood cells. <ref> Weinberg, I. (April 2010). Janus Kinase (Jak2)”. Vascular Medicind; Angiolgist http://www.angiologist.com/general-medicine/janus-kinase-2-jak2/</ref> The Jak2 Signal Transducers and Activators of Transcription (STAT) pathway is what influences the kinase ability. The janus kinase-STAT pathway is the central path taken for such cell signal transcription though the erythropoietin receptor. <ref> O'Shea, J., Gadina, M., & Chen, X. (2005). Structure of a janus kinase: molecular insights and prospects for optimizing a new class of immunosuppressants. The Journal of the American Society of Hematology, 106(3), 765-766. doi: 10.1182/blood-2005-05-1947 http://bloodjournal.hematologylibrary.org/content/106/3/765.full </ref> Under normal conditions, various levels of regulation maintain Jak2 in its inactive form until receptor activation occurs and involve interactions of the pseudokinase domain (JH2) and FERM domain (JH4 to -7) with the kinase domain (JH1). <ref> Funakoshi-Tago, M., Pelletier, S., & Moritake, H. (2008). Jak2 ferm domain interaction with the erythropoietin receptor regulates jak2 kinase activity. Molecular and Cellular Biology, 28(5), 1792-1801. doi: 10.1128/MCB.01447-07 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258779/ </ref> | |||
