Sandbox Reserved 595: Difference between revisions
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The ApoE gene stores the information responsible for the protein apolipoprotein E. ApoE's cytogenic location is on the long q arm of chromosome 19, in the 13.2 position (19q13.2). It stretches from base pair 45,409,038 to bp 45,412,649 (X). Polymorphisms for this gene include three main alleles, epsilon 2, epsilon 3, and epsilon 4 (W). The ε3 allele is the most frequent in all human groups. ε4 has a higher frequency in populations such as Pygmies and Khoisan, Aboriginies of Malaysia and Australia, Papuas, some Native Americans, and Lapps. The frequency of ε2 fluctuates without an apparent trend; but, it is abscent in Native American populations (W). | The ApoE gene stores the information responsible for the protein apolipoprotein E. ApoE's cytogenic location is on the long q arm of chromosome 19, in the 13.2 position (19q13.2). It stretches from base pair 45,409,038 to bp 45,412,649 (X). Polymorphisms for this gene include three main alleles, epsilon 2, epsilon 3, and epsilon 4 (W). The ε3 allele is the most frequent in all human groups. ε4 has a higher frequency in populations such as Pygmies and Khoisan, Aboriginies of Malaysia and Australia, Papuas, some Native Americans, and Lapps. The frequency of ε2 fluctuates without an apparent trend; but, it is abscent in Native American populations (W). | ||
=Structure= | =Structure= | ||
<Structure load='1NFN' size='500' frame='true' align='right' caption='3-D Rendering of ApoE3' scene='Insert optional scene name here' /> | <Structure load='1NFN' size='500' frame='true' align='right' caption='3-D Rendering of ApoE3 N-terminus' scene='Insert optional scene name here' /> | ||
==Primary Structural Features== | ==Primary Structural Features== | ||
Apolipoprotein E is a polymorphic glycoprotein that consists of 299 amino acids (A,F). It has a molecular weight of 34kDa (G). The primary structure for ApoE is rich in the amino acid argine (W). | Apolipoprotein E is a polymorphic glycoprotein that consists of 299 amino acids (A,F). It has a molecular weight of 34kDa (G). The primary structure for ApoE is rich in the amino acid argine (W). | ||
