4ggm: Difference between revisions
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==Structure of LpxI== | |||
=== | <StructureSection load='4ggm' size='340' side='right' caption='[[4ggm]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4ggm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caulobacter_crescentus_na1000 Caulobacter crescentus na1000]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GGM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GGM FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LP5:(R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL)+3-HYDROXYTETRADECANOATE'>LP5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ggi|4ggi]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">7330127, CCNA_01987, lpxI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=565050 Caulobacter crescentus NA1000])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-2,3-diacylglucosamine_diphosphatase UDP-2,3-diacylglucosamine diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.54 3.6.1.54] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ggm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ggm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ggm RCSB], [http://www.ebi.ac.uk/pdbsum/4ggm PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Enzymes in lipid metabolism acquire and deliver hydrophobic substrates and products from within lipid bilayers. The structure at 2.55 A of one isozyme of a constitutive enzyme in lipid A biosynthesis, LpxI from Caulobacter crescentus, has a novel fold. Two domains close around a completely sequestered substrate, UDP-2,3-diacylglucosamine, and open to release products either to the neighboring enzyme in a putative multienzyme complex or to the bilayer. Mutation analysis identifies Asp225 as key to Mg(2+)-catalyzed diphosphate hydrolysis. These structures provide snapshots of the enzymatic synthesis of a critical lipid A precursor. | |||
LpxI structures reveal how a lipid A precursor is synthesized.,Metzger LE 4th, Lee JK, Finer-Moore JS, Raetz CR, Stroud RM Nat Struct Mol Biol. 2012 Nov;19(11):1132-8. doi: 10.1038/nsmb.2393. Epub 2012, Oct 7. PMID:23042606<ref>PMID:23042606</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Caulobacter crescentus na1000]] | [[Category: Caulobacter crescentus na1000]] | ||
[[Category: UDP-2,3-diacylglucosamine diphosphatase]] | [[Category: UDP-2,3-diacylglucosamine diphosphatase]] | ||
[[Category: CSMP, Center for Structures of Membrane Proteins | [[Category: CSMP, Center for Structures of Membrane Proteins]] | ||
[[Category: Finer-Moore, J S | [[Category: Finer-Moore, J S]] | ||
[[Category: IV, L E.Metzger | [[Category: IV, L E.Metzger]] | ||
[[Category: Lee, J K | [[Category: Lee, J K]] | ||
[[Category: Raetz, C R.H | [[Category: Raetz, C R.H]] | ||
[[Category: Stroud, R M | [[Category: Stroud, R M]] | ||
[[Category: Center for structures of membrane protein]] | [[Category: Center for structures of membrane protein]] | ||
[[Category: Csmp]] | [[Category: Csmp]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Lipid binding]] | [[Category: Lipid binding]] | ||
[[Category: Protein structure initiative]] | [[Category: PSI, Protein structure initiative]] | ||
[[Category: Psi-biology]] | [[Category: Psi-biology]] | ||
[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
Revision as of 11:42, 21 December 2014
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Caulobacter crescentus na1000
- UDP-2,3-diacylglucosamine diphosphatase
- CSMP, Center for Structures of Membrane Proteins
- Finer-Moore, J S
- IV, L E.Metzger
- Lee, J K
- Raetz, C R.H
- Stroud, R M
- Center for structures of membrane protein
- Csmp
- Hydrolase
- Lipid binding
- PSI, Protein structure initiative
- Psi-biology
- Structural genomic
