3zn3: Difference between revisions
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{{STRUCTURE_3zn3| PDB=3zn3 | SCENE= }} | {{STRUCTURE_3zn3| PDB=3zn3 | SCENE= }} | ||
===N-terminal domain of S. pombe Cdc23 APC subunit=== | ===N-terminal domain of S. pombe Cdc23 APC subunit=== | ||
{{ABSTRACT_PUBMED_23583778}} | |||
==Function== | ==Function== | ||
Revision as of 06:41, 2 May 2013
N-terminal domain of S. pombe Cdc23 APC subunit
Template:ABSTRACT PUBMED 23583778
Function
[APC8_SCHPO] Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in promoting metaphase to anaphase transition via the ubiquitination of specific mitotic substrates.[1]
About this Structure
3zn3 is a 1 chain structure with sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.
