2m6n: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "2m6n" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_2m6n| PDB=2m6n | SCENE= }} | |||
===3D solution structure of EMI1 (Early Mitotic Inhibitor 1)=== | |||
{{ABSTRACT_PUBMED_23708605}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/FBX5_HUMAN FBX5_HUMAN]] Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.<ref>PMID:11988738</ref> <ref>PMID:16921029</ref> | |||
==About this Structure== | |||
[[2m6n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M6N OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023708605</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Brown, N G.]] | |||
[[Category: Frye, J J.]] | |||
[[Category: Jarvis, M.]] | |||
[[Category: Kriwacki, R W.]] | |||
[[Category: Nourse, A.]] | |||
[[Category: Peters, J.]] | |||
[[Category: Petzold, G.]] | |||
[[Category: Royappa, G R.]] | |||
[[Category: Schulman, B A.]] | |||
[[Category: Stark, H.]] | |||
[[Category: Watson, E R.]] | |||
[[Category: Apc]] | |||
[[Category: Cell cycle]] | |||
[[Category: E3 ligase]] | |||
[[Category: Emi1]] | |||
[[Category: Zbr]] | |||
Revision as of 15:34, 19 June 2013
3D solution structure of EMI1 (Early Mitotic Inhibitor 1)
Template:ABSTRACT PUBMED 23708605
Function
[FBX5_HUMAN] Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.[1] [2]
About this Structure
2m6n is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- Frye JJ, Brown NG, Petzold G, Watson ER, Grace CR, Nourse A, Jarvis MA, Kriwacki RW, Peters JM, Stark H, Schulman BA. Electron microscopy structure of human APC/C-EMI1 reveals multimodal mechanism of E3 ligase shutdown. Nat Struct Mol Biol. 2013 May 26. doi: 10.1038/nsmb.2593. PMID:23708605 doi:10.1038/nsmb.2593
- ↑ Hsu JY, Reimann JD, Sorensen CS, Lukas J, Jackson PK. E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). Nat Cell Biol. 2002 May;4(5):358-66. PMID:11988738 doi:10.1038/ncb785
- ↑ Miller JJ, Summers MK, Hansen DV, Nachury MV, Lehman NL, Loktev A, Jackson PK. Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. Genes Dev. 2006 Sep 1;20(17):2410-20. Epub 2006 Aug 18. PMID:16921029 doi:gad.1454006
