4amv: Difference between revisions
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{{STRUCTURE_4amv| PDB=4amv | SCENE= }} | |||
===E.COLI GLUCOSAMINE-6P SYNTHASE IN COMPLEX WITH FRUCTOSE-6P=== | |||
{{ABSTRACT_PUBMED_16339762}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GLMS_ECOLI GLMS_ECOLI]] Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | |||
==About this Structure== | |||
[[4amv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2bpl 2bpl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMV OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:016339762</ref><ref group="xtra">PMID:017322533</ref><ref group="xtra">PMID:018295797</ref><references group="xtra"/><references/> | |||
[[Category: Escherichia coli]] | |||
[[Category: Golinelli-Pimpaneau, B.]] | |||
[[Category: Mouilleron, S.]] | |||
[[Category: Ammonia channeling]] | |||
[[Category: Glucosamine 6- phosphate synthase]] | |||
[[Category: Glutamine amidotransferase]] | |||
[[Category: N terminal nucleophile]] | |||
[[Category: Transferase]] | |||
Revision as of 11:16, 24 April 2013
E.COLI GLUCOSAMINE-6P SYNTHASE IN COMPLEX WITH FRUCTOSE-6P
Template:ABSTRACT PUBMED 16339762
Function
[GLMS_ECOLI] Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
About this Structure
4amv is a 3 chain structure with sequence from Escherichia coli. This structure supersedes the now removed PDB entry 2bpl. Full crystallographic information is available from OCA.
Reference
- Mouilleron S, Badet-Denisot MA, Golinelli-Pimpaneau B. Glutamine binding opens the ammonia channel and activates glucosamine-6P synthase. J Biol Chem. 2006 Feb 17;281(7):4404-12. Epub 2005 Dec 9. PMID:16339762 doi:10.1074/jbc.M511689200
- Mouilleron S, Golinelli-Pimpaneau B. Domain motions of glucosamine-6P synthase: comparison of the anisotropic displacements in the crystals and the catalytic hinge-bending rotation. Protein Sci. 2007 Mar;16(3):485-93. PMID:17322533 doi:16/3/485
- Mouilleron S, Badet-Denisot MA, Golinelli-Pimpaneau B. Ordering of C-terminal loop and glutaminase domains of glucosamine-6-phosphate synthase promotes sugar ring opening and formation of the ammonia channel. J Mol Biol. 2008 Apr 4;377(4):1174-85. Epub 2008 Feb 4. PMID:18295797 doi:10.1016/j.jmb.2008.01.077
