4bh0: Difference between revisions

Line 1:

'~~''Unreleased structure'''~~

===H5 (tyTy) Influenza Virus Haemagglutinin in Complex with Human Receptor Analogue 6'-SLN===

~~The entry 4bh0 is ON HOLD until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/Q207Z6_9INFA Q207Z6_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]

~~Authors~~: ~~Xiong~~, X., Coombs, P.~~, R Martin~~, S., Liu, J., ~~Xiao~~, H., McCauley, J.W., ~~Locher, K~~., Walker, P.A., ~~Collins, P.J~~., ~~Kawaoka, Y., Skehel, J.J., Gamblin, S.J~~.

==About this Structure==

[[4bh0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/turkey/turkey/1/2005(h5n1)) Influenza a virus (a/turkey/turkey/1/2005(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BH0 OCA].

~~Description~~: ~~H5 (tyTy) Influenza~~ Virus ~~Haemagglutinin in Complex with Human Receptor Analogue 6'-SLN~~

[[Category: Collins, P J.]]

[[Category: Coombs, P J.]]

[[Category: Gamblin, S J.]]

[[Category: Kawaoka, Y.]]

[[Category: Liu, J.]]

[[Category: Locher, K.]]

[[Category: Martin, S R.]]

[[Category: McCauley, J W.]]

[[Category: Skehel, J J.]]

[[Category: Walker, P A.]]

[[Category: Xiao, H.]]

[[Category: Xiong, X.]]

[[Category: Bird flu]]

[[Category: N-glycosylation]]

[[Category: Viral protein]]

[[Category: Virus receptor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4bh0|  PDB=4bh0  |  SCENE=  }}
+===H5 (tyTy) Influenza Virus Haemagglutinin in Complex with Human Receptor Analogue 6'-SLN===
-The entry 4bh0 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/Q207Z6_9INFA Q207Z6_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
-Authors: Xiong, X., Coombs, P., R Martin, S., Liu, J., Xiao, H., McCauley, J.W., Locher, K., Walker, P.A., Collins, P.J., Kawaoka, Y., Skehel, J.J., Gamblin, S.J.
+==About this Structure==
+[[4bh0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/turkey/turkey/1/2005(h5n1)) Influenza a virus (a/turkey/turkey/1/2005(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BH0 OCA].
-Description: H5 (tyTy) Influenza Virus Haemagglutinin in Complex with Human Receptor Analogue 6'-SLN
+[[Category: Collins, P J.]]
+[[Category: Coombs, P J.]]
+[[Category: Gamblin, S J.]]
+[[Category: Kawaoka, Y.]]
+[[Category: Liu, J.]]
+[[Category: Locher, K.]]
+[[Category: Martin, S R.]]
+[[Category: McCauley, J W.]]
+[[Category: Skehel, J J.]]
+[[Category: Walker, P A.]]
+[[Category: Xiao, H.]]
+[[Category: Xiong, X.]]
+[[Category: Bird flu]]
+[[Category: N-glycosylation]]
+[[Category: Viral protein]]
+[[Category: Virus receptor]]