4bh4: Difference between revisions

Line 1:

'~~''Unreleased structure'''~~

===Haemagglutinin from a Transmissible Mutant H5 Influenza Virus in Complex with Avian Receptor Analogue 3'-SLN===

~~The entry 4bh4 is ON HOLD until sometime~~ in the ~~future~~

==Function==

[[http://www.uniprot.org/uniprot/Q5EP31_9INFA Q5EP31_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]

~~Authors~~: ~~Xiong~~, X., Coombs, P.~~, R Martin~~, S., Liu, J., ~~Xiao~~, H., McCauley, J.W., ~~Locher, K~~., Walker, P.A., ~~Collins, P.J~~., ~~Kawaoka, Y., Skehel, J.J., Gamblin, S.J~~.

==About this Structure==

[[4bh4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/viet_nam/1203/2004(h5n1)) Influenza a virus (a/viet nam/1203/2004(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BH4 OCA].

~~Description~~: ~~Haemagglutinin from a Transmissible Mutant H5 Influenza~~ Virus ~~in Complex with Avian Receptor Analogue 3'-SLN~~

[[Category: Collins, P J.]]

[[Category: Coombs, P J.]]

[[Category: Gamblin, S J.]]

[[Category: Kawaoka, Y.]]

[[Category: Liu, J.]]

[[Category: Locher, K.]]

[[Category: Martin, S R.]]

[[Category: McCauley, J W.]]

[[Category: Skehel, J J.]]

[[Category: Walker, P A.]]

[[Category: Xiao, H.]]

[[Category: Xiong, X.]]

[[Category: Bird flu]]

[[Category: N-glycosylation]]

[[Category: Viral protein]]

[[Category: Virus receptor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4bh4|  PDB=4bh4  |  SCENE=  }}
+===Haemagglutinin from a Transmissible Mutant H5 Influenza Virus in Complex with Avian Receptor Analogue 3'-SLN===
-The entry 4bh4 is ON HOLD  until sometime in the future
+==Function==
+[[http://www.uniprot.org/uniprot/Q5EP31_9INFA Q5EP31_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
-Authors: Xiong, X., Coombs, P., R Martin, S., Liu, J., Xiao, H., McCauley, J.W., Locher, K., Walker, P.A., Collins, P.J., Kawaoka, Y., Skehel, J.J., Gamblin, S.J.
+==About this Structure==
+[[4bh4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/viet_nam/1203/2004(h5n1)) Influenza a virus (a/viet nam/1203/2004(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BH4 OCA].
-Description: Haemagglutinin from a Transmissible Mutant H5 Influenza Virus in Complex with Avian Receptor Analogue 3'-SLN
+[[Category: Collins, P J.]]
+[[Category: Coombs, P J.]]
+[[Category: Gamblin, S J.]]
+[[Category: Kawaoka, Y.]]
+[[Category: Liu, J.]]
+[[Category: Locher, K.]]
+[[Category: Martin, S R.]]
+[[Category: McCauley, J W.]]
+[[Category: Skehel, J J.]]
+[[Category: Walker, P A.]]
+[[Category: Xiao, H.]]
+[[Category: Xiong, X.]]
+[[Category: Bird flu]]
+[[Category: N-glycosylation]]
+[[Category: Viral protein]]
+[[Category: Virus receptor]]