4i0i: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4i0i|  PDB=4i0i  |  SCENE=  }}
+===SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors===
-The entry 4i0i is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
-Authors: Yao, N., Brecht, E.
+==About this Structure==
+[[4i0i]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I0I OCA].
-Description: SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Memapsin 2]]
+[[Category: Brecht, E.]]
+[[Category: Yao, N.]]
+[[Category: Aspartic protease]]
+[[Category: Bace]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]
+[[Category: Hydrolysis]]

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