4j4q: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4j4q|  PDB=4j4q  |  SCENE=  }}
===Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside===
{{ABSTRACT_PUBMED_24038729}}


The entry 4j4q is ON HOLD  until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>  [[http://www.uniprot.org/uniprot/GNAT1_BOVIN GNAT1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.


Authors: Park, J.H., Morizumi, T., Li, Y., Hong, J.E., Pai, E.F., Hofmann, K.P., Choe, H.W., Ernst, O.P.
==About this Structure==
[[4j4q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4Q OCA].  


Description: Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside
==Reference==
<ref group="xtra">PMID:024038729</ref><references group="xtra"/><references/>
[[Category: Bos taurus]]
[[Category: Choe, H W.]]
[[Category: Ernst, O P.]]
[[Category: Hofmann, K P.]]
[[Category: Hong, J E.]]
[[Category: Li, Y.]]
[[Category: Morizumi, T.]]
[[Category: Pai, E F.]]
[[Category: Park, J H.]]
[[Category: G-protein coupled receptor]]
[[Category: Galpha subunit]]
[[Category: Glycoprotein]]
[[Category: Gtp-binding]]
[[Category: Lipoprotein]]
[[Category: Membrane]]
[[Category: Myristate]]
[[Category: Nucleotide-binding]]
[[Category: Photoreceptor protein]]
[[Category: Receptor retinal protein]]
[[Category: Retinal binding]]
[[Category: Sensory transduction]]
[[Category: Signaling protein]]
[[Category: Transducer]]
[[Category: Transmembrane]]

Revision as of 09:44, 30 October 2013

Template:STRUCTURE 4j4q

Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside

Template:ABSTRACT PUBMED 24038729

Function

[OPSD_BOVIN] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).[1] [2] [GNAT1_BOVIN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.

About this Structure

4j4q is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

  1. Park JH, Morizumi T, Li Y, Hong JE, Pai EF, Hofmann KP, Choe HW, Ernst OP. Opsin, a structural model for olfactory receptors? Angew Chem Int Ed Engl. 2013 Oct 11;52(42):11021-4. doi: 10.1002/anie.201302374. , Epub 2013 Aug 26. PMID:24038729 doi:https://dx.doi.org/10.1002/anie.201302374
  1. ↑ Nakamichi H, Okada T. Local peptide movement in the photoreaction intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12729-34. Epub 2006 Aug 14. PMID:16908857
  2. ↑ Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. Epub 2006 Oct 23. PMID:17060607

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