4jff: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Preservation of peptide specificity during TCR-MHC contact dominated affinity enhancement of a melanoma-specific TCR===

The ~~entry 4jff~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>

~~Authors~~: ~~Rizkallah, P~~.J.~~, Cole, D~~.K.~~, Madura, F~~.~~, Sewell, A~~.K.

==Function==

[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

~~Description~~: ~~Preservation of peptide specificity during TCR~~-~~MHC contact dominated~~ affinity ~~enhancement of a melanoma-specific TCR~~

==About this Structure==

[[4jff]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JFF OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Cole, D K.]]

[[Category: Madura, F.]]

[[Category: Rizkallah, P J.]]

[[Category: Sewell, A K.]]

[[Category: High affinity]]

[[Category: Hla]]

[[Category: Immune system]]

[[Category: Melanoma motif]]

[[Category: Tcr]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4jff|  PDB=4jff  |  SCENE=  }}
+===Preservation of peptide specificity during TCR-MHC contact dominated affinity enhancement of a melanoma-specific TCR===
+{{ABSTRACT_PUBMED_23698002}}
-The entry 4jff is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>   Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
-Authors: Rizkallah, P.J., Cole, D.K., Madura, F., Sewell, A.K.
+==Function==
+[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
-Description: Preservation of peptide specificity during TCR-MHC contact dominated affinity enhancement of a melanoma-specific TCR
+==About this Structure==
+[[4jff]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JFF OCA].
+==Reference==
+<ref group="xtra">PMID:023698002</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Cole, D K.]]
+[[Category: Madura, F.]]
+[[Category: Rizkallah, P J.]]
+[[Category: Sewell, A K.]]
+[[Category: High affinity]]
+[[Category: Hla]]
+[[Category: Immune system]]
+[[Category: Melanoma motif]]
+[[Category: Tcr]]