4jjn: Difference between revisions

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~~'''Unreleased~~ structure~~'''~~

===Crystal structure of heterochromatin protein Sir3 in complex with a silenced yeast nucleosome===

~~The entry 4jjn~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/H2B2_YEAST H2B2_YEAST]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:12152067</ref> <ref>PMID:14752010</ref> <ref>PMID:15280549</ref> <ref>PMID:15652479</ref> <ref>PMID:15970663</ref> <ref>PMID:15632065</ref> <ref>PMID:16598039</ref> [[http://www.uniprot.org/uniprot/H2A2_YEAST H2A2_YEAST]] Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11140636</ref> <ref>PMID:15458641</ref> <ref>PMID:15610741</ref> <ref>PMID:16299494</ref> [[http://www.uniprot.org/uniprot/SIR3_YEAST SIR3_YEAST]] The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.

~~Authors~~: ~~Wang, F~~.~~, Li, G~~.~~, Mohammed, A~~.~~, Lu, C~~.~~, Currie, M~~.~~, Johnson, A~~.~~, Moazed, D~~.

==About this Structure==

[[4jjn]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJN OCA].

~~Description~~: ~~Crystal structure of heterochromatin~~ protein ~~Sir3 in~~ complex ~~with a silenced yeast nucleosome~~

==Reference==

[[Category: Saccharomyces cerevisiae s288c]]

[[Category: Currie, M.]]

[[Category: Johnson, A.]]

[[Category: Li, G.]]

[[Category: Lu, C.]]

[[Category: Moazed, D.]]

[[Category: Mohammed, A.]]

[[Category: Wang, F.]]

[[Category: Bah domain]]

[[Category: Dna binding protein-dna complex]]

[[Category: Silencing]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4jjn|  PDB=4jjn  |  SCENE=  }}
+===Crystal structure of heterochromatin protein Sir3 in complex with a silenced yeast nucleosome===
+{{ABSTRACT_PUBMED_23650358}}
-The entry 4jjn is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/H2B2_YEAST H2B2_YEAST]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:12152067</ref> <ref>PMID:14752010</ref> <ref>PMID:15280549</ref> <ref>PMID:15652479</ref> <ref>PMID:15970663</ref> <ref>PMID:15632065</ref> <ref>PMID:16598039</ref>  [[http://www.uniprot.org/uniprot/H2A2_YEAST H2A2_YEAST]] Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11140636</ref> <ref>PMID:15458641</ref> <ref>PMID:15610741</ref> <ref>PMID:16299494</ref>  [[http://www.uniprot.org/uniprot/SIR3_YEAST SIR3_YEAST]] The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.
-Authors: Wang, F., Li, G., Mohammed, A., Lu, C., Currie, M., Johnson, A., Moazed, D.
+==About this Structure==
+[[4jjn]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJN OCA].
-Description: Crystal structure of heterochromatin protein Sir3 in complex with a silenced yeast nucleosome
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Saccharomyces cerevisiae s288c]]
+[[Category: Currie, M.]]
+[[Category: Johnson, A.]]
+[[Category: Li, G.]]
+[[Category: Lu, C.]]
+[[Category: Moazed, D.]]
+[[Category: Mohammed, A.]]
+[[Category: Wang, F.]]
+[[Category: Bah domain]]
+[[Category: Dna binding protein-dna complex]]
+[[Category: Silencing]]