4jk6: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Human urokinase-type Plasminogen Activator (uPA) in complex with a bicyclic peptide inhibitor (UK18-D-Aba)===

The ~~entry 4jk6~~ is ~~ON HOLD~~

==Disease==

[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[http://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>

~~Authors~~: ~~Buth, S~~.A.~~, Leiman, P.G., Chen, S., Heinis, C~~.

==Function==

[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

~~Description~~: ~~Human urokinase~~-~~type Plasminogen Activator (uPA) in complex with a bicyclic~~ peptide inhibitor ~~(UK18~~-D-~~Aba)~~

==About this Structure==

[[4jk6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JK6 OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: U-plasminogen activator]]

[[Category: Buth, S A.]]

[[Category: Chen, S.]]

[[Category: Heinis, C.]]

[[Category: Leiman, P G.]]

[[Category: Bicyclic peptide inhibitor]]

[[Category: Chymotrypsin fold]]

[[Category: D-amino acid]]

[[Category: Hydrolase-hydrolase inhibitor complex]]

[[Category: Serine protease]]

[[Category: Urokinase-type plasminogen activator]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4jk6|  PDB=4jk6  |  SCENE=  }}
+===Human urokinase-type Plasminogen Activator (uPA) in complex with a bicyclic peptide inhibitor (UK18-D-Aba)===
+{{ABSTRACT_PUBMED_23828687}}
-The entry 4jk6 is ON HOLD
+==Disease==
+[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[http://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
-Authors: Buth, S.A., Leiman, P.G., Chen, S., Heinis, C.
+==Function==
+[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
-Description: Human urokinase-type Plasminogen Activator (uPA) in complex with a bicyclic peptide inhibitor (UK18-D-Aba)
+==About this Structure==
+[[4jk6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JK6 OCA].
+==Reference==
+<ref group="xtra">PMID:023828687</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: U-plasminogen activator]]
+[[Category: Buth, S A.]]
+[[Category: Chen, S.]]
+[[Category: Heinis, C.]]
+[[Category: Leiman, P G.]]
+[[Category: Bicyclic peptide inhibitor]]
+[[Category: Chymotrypsin fold]]
+[[Category: D-amino acid]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]
+[[Category: Serine protease]]
+[[Category: Urokinase-type plasminogen activator]]