4jlk: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Human dCK C4S-S74E mutant in complex with UDP and the F2.2.1 inhibitoR (2-[({2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-5-METHYL-1,3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE)===

~~The entry 4jlk~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN]] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref>

~~Authors~~: ~~Nomme, J~~.~~, Lavie, A~~.

==About this Structure==

[[4jlk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JLK OCA].

~~Description~~:

==Reference==

[[Category: Deoxycytidine kinase]]

[[Category: Homo sapiens]]

[[Category: Lavie, A.]]

[[Category: Nomme, J.]]

[[Category: Kinase]]

[[Category: Phosphoryl transfer]]

[[Category: Phosphorylation]]

[[Category: Transferase-transferase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4jlk|  PDB=4jlk  |  SCENE=  }}
+===Human dCK C4S-S74E mutant in complex with UDP and the F2.2.1 inhibitoR (2-[({2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-5-METHYL-1,3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE)===
+{{ABSTRACT_PUBMED_23947754}}
-The entry 4jlk is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN]] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref>
-Authors: Nomme, J., Lavie, A.
+==About this Structure==
+[[4jlk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JLK OCA].
-Description:
+==Reference==
+<ref group="xtra">PMID:023947754</ref><references group="xtra"/><references/>
+[[Category: Deoxycytidine kinase]]
+[[Category: Homo sapiens]]
+[[Category: Lavie, A.]]
+[[Category: Nomme, J.]]
+[[Category: Kinase]]
+[[Category: Phosphoryl transfer]]
+[[Category: Phosphorylation]]
+[[Category: Transferase-transferase inhibitor complex]]