4jnc: Difference between revisions
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{{STRUCTURE_4jnc| PDB=4jnc | SCENE= }} | |||
===Soluble Epoxide Hydrolase complexed with a carboxamide inhibitor=== | |||
{{ABSTRACT_PUBMED_23664879}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/HYES_HUMAN HYES_HUMAN]] Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.<ref>PMID:12574508</ref> <ref>PMID:12574510</ref> | |||
==About this Structure== | |||
[[4jnc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JNC OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023664879</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Shewchuk, L M.]] | |||
[[Category: Epoxide hydrolase]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
