4jof: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===CFTR Associated Ligand (CAL) PDZ domain bound to peptide L-iCAL36 (ANSRLPTSII)===

~~The entry 4jof~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>

~~Authors~~: ~~Amacher, J~~.F.~~, Madden, D~~.R.

==Function==

[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref>

~~Description~~: ~~CFTR Associated Ligand (CAL) PDZ domain bound to peptide L~~-~~iCAL36 (ANSRLPTSII)~~

==About this Structure==

[[4jof]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JOF OCA].

==Reference==

[[Category: Amacher, J F.]]

[[Category: Madden, D R.]]

[[Category: Cal]]

[[Category: Cftr associated ligand]]

[[Category: Fig]]

[[Category: Pdz]]

[[Category: Peptide binding protein]]

[[Category: Pist]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4jof|  PDB=4jof  |  SCENE=  }}
+===CFTR Associated Ligand (CAL) PDZ domain bound to peptide L-iCAL36 (ANSRLPTSII)===
+{{ABSTRACT_PUBMED_24210758}}
-The entry 4jof is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>
-Authors: Amacher, J.F., Madden, D.R.
+==Function==
+[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref>
-Description: CFTR Associated Ligand (CAL) PDZ domain bound to peptide L-iCAL36 (ANSRLPTSII)
+==About this Structure==
+[[4jof]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JOF OCA].
+==Reference==
+<ref group="xtra">PMID:024210758</ref><references group="xtra"/><references/>
+[[Category: Amacher, J F.]]
+[[Category: Madden, D R.]]
+[[Category: Cal]]
+[[Category: Cftr associated ligand]]
+[[Category: Fig]]
+[[Category: Pdz]]
+[[Category: Peptide binding protein]]
+[[Category: Pist]]