4jqv: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===HLA-B*18:01 in complex with Epstein-Barr virus BZLF1-derived peptide (residues 173-180)===

The ~~entry 4jqv~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>

~~Authors~~: ~~Theodossis, A~~.~~, Welland, A~~.~~, Gras, S~~.~~, Rossjohn, J~~.

==Function==

[[http://www.uniprot.org/uniprot/1B18_HUMAN 1B18_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

~~Description~~:

==About this Structure==

[[4jqv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JQV OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Gras, S.]]

[[Category: Rossjohn, J.]]

[[Category: Theodossis, A.]]

[[Category: Welland, A.]]

[[Category: Antigen presentation]]

[[Category: Extracellular]]

[[Category: Immune system]]

[[Category: Immunoglobulin fold]]

[[Category: T-cell receptor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4jqv|  PDB=4jqv  |  SCENE=  }}
+===HLA-B*18:01 in complex with Epstein-Barr virus BZLF1-derived peptide (residues 173-180)===
+{{ABSTRACT_PUBMED_23749632}}
-The entry 4jqv is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>   Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
-Authors: Theodossis, A., Welland, A., Gras, S., Rossjohn, J.
+==Function==
+[[http://www.uniprot.org/uniprot/1B18_HUMAN 1B18_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
-Description:
+==About this Structure==
+[[4jqv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JQV OCA].
+==Reference==
+<ref group="xtra">PMID:023749632</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Gras, S.]]
+[[Category: Rossjohn, J.]]
+[[Category: Theodossis, A.]]
+[[Category: Welland, A.]]
+[[Category: Antigen presentation]]
+[[Category: Extracellular]]
+[[Category: Immune system]]
+[[Category: Immunoglobulin fold]]
+[[Category: T-cell receptor]]