4jr0: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Human procaspase-3 bound to Ac-DEVD-CMK===

~~The entry 4jr0 is ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>

~~Authors~~: ~~Thomsen, N~~.D.~~, Wells, J~~.A.

==About this Structure==

[[4jr0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JR0 OCA].

~~Description~~:

==Reference==

[[Category: Caspase-3]]

[[Category: Homo sapiens]]

[[Category: Thomsen, N D.]]

[[Category: Wells, J A.]]

[[Category: Activity based probe]]

[[Category: Apoptosis]]

[[Category: Caspase]]

[[Category: Hydrolase-hydrolase inhibitor complex]]

[[Category: Irreversible inhibitor]]

[[Category: Proenzyme]]

[[Category: Protease]]

[[Category: Protein-peptide complex]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4jr0|  PDB=4jr0  |  SCENE=  }}
+===Human procaspase-3 bound to Ac-DEVD-CMK===
-The entry 4jr0 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
-Authors: Thomsen, N.D., Wells, J.A.
+==About this Structure==
+[[4jr0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JR0 OCA].
-Description:
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Caspase-3]]
+[[Category: Homo sapiens]]
+[[Category: Thomsen, N D.]]
+[[Category: Wells, J A.]]
+[[Category: Activity based probe]]
+[[Category: Apoptosis]]
+[[Category: Caspase]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]
+[[Category: Irreversible inhibitor]]
+[[Category: Proenzyme]]
+[[Category: Protease]]
+[[Category: Protein-peptide complex]]