4jv6: Difference between revisions
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{{STRUCTURE_4jv6| PDB=4jv6 | SCENE= }} | |||
===The crystal structure of PDE6D in complex to inhibitor-1=== | |||
{{ABSTRACT_PUBMED_23698361}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN]] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity). | |||
==About this Structure== | |||
[[4jv6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JV6 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023698361</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Bastiaens, P.]] | |||
[[Category: Chandra, A.]] | |||
[[Category: Gunther, Z.]] | |||
[[Category: Hahn, S.]] | |||
[[Category: Hoffmann, M.]] | |||
[[Category: Ismail, S.]] | |||
[[Category: Papke, B.]] | |||
[[Category: Triola, G.]] | |||
[[Category: Vartak, N.]] | |||
[[Category: Waldmann, H.]] | |||
[[Category: Wittinghofer, A.]] | |||
[[Category: Gdi-like solubilizing factor]] | |||
[[Category: Immunoglobulin-like beta-sandwich]] | |||
[[Category: Prenyl binding protein]] | |||
[[Category: Protein binding-inhibitor complex]] | |||
Revision as of 15:49, 19 June 2013
The crystal structure of PDE6D in complex to inhibitor-1
Template:ABSTRACT PUBMED 23698361
Function
[PDE6D_HUMAN] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).
About this Structure
4jv6 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Zimmermann G, Papke B, Ismail S, Vartak N, Chandra A, Hoffmann M, Hahn SA, Triola G, Wittinghofer A, Bastiaens PI, Waldmann H. Small molecule inhibition of the KRAS-PDEdelta interaction impairs oncogenic KRAS signalling. Nature. 2013 May 30;497(7451):638-42. doi: 10.1038/nature12205. Epub 2013 May 22. PMID:23698361 doi:10.1038/nature12205
