4jzc: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Angiopoietin-2 fibrinogen domain TAG mutant===

~~The entry 4jzc is ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/ANGP2_HUMAN ANGP2_HUMAN]] Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.<ref>PMID:9204896</ref> <ref>PMID:15284220</ref> <ref>PMID:19116766</ref> <ref>PMID:19223473</ref>

~~Authors~~: ~~Yu, X~~.~~, Seegar, T~~.C.M.~~, Dalton, A~~.C.~~, Tzvetkova~~-~~Robev, D., Goldgur, Y., Nikolov, D.B., Barton, W.A~~.

==About this Structure==

[[4jzc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JZC OCA].

~~Description~~: ~~Angiopoietin~~-~~2 fibrinogen~~ domain ~~TAG mutant~~

==Reference==

[[Category: Homo sapiens]]

[[Category: Barton, W A.]]

[[Category: Dalton, A C.]]

[[Category: Goldgur, Y.]]

[[Category: Nikolov, D B.]]

[[Category: Seegar, T C.M.]]

[[Category: Tzvetkova-Robev, D.]]

[[Category: Yu, X.]]

[[Category: Fibrinogen-like receptor-binding domain]]

[[Category: Signaling protein]]

[[Category: Tie2]]

[[Category: Tie2 receptor-binding]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4jzc|  PDB=4jzc  |  SCENE=  }}
+===Angiopoietin-2 fibrinogen domain TAG mutant===
+{{ABSTRACT_PUBMED_23592718}}
-The entry 4jzc is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/ANGP2_HUMAN ANGP2_HUMAN]] Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.<ref>PMID:9204896</ref> <ref>PMID:15284220</ref> <ref>PMID:19116766</ref> <ref>PMID:19223473</ref>
-Authors: Yu, X., Seegar, T.C.M., Dalton, A.C., Tzvetkova-Robev, D., Goldgur, Y., Nikolov, D.B., Barton, W.A.
+==About this Structure==
+[[4jzc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JZC OCA].
-Description: Angiopoietin-2 fibrinogen domain TAG mutant
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Barton, W A.]]
+[[Category: Dalton, A C.]]
+[[Category: Goldgur, Y.]]
+[[Category: Nikolov, D B.]]
+[[Category: Seegar, T C.M.]]
+[[Category: Tzvetkova-Robev, D.]]
+[[Category: Yu, X.]]
+[[Category: Fibrinogen-like receptor-binding domain]]
+[[Category: Signaling protein]]
+[[Category: Tie2]]
+[[Category: Tie2 receptor-binding]]