4jzp: Difference between revisions
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{{STRUCTURE_4jzp| PDB=4jzp | SCENE= }} | |||
===Crystal structure of BAP31 vDED at acidic pH=== | |||
{{ABSTRACT_PUBMED_23967155}} | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/BAP31_HUMAN BAP31_HUMAN]] BCAP31 is deleted in the chromosome Xq28 deletion syndrome which involves BCAP31 and the and the promoter region of ABCD1. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BAP31_HUMAN BAP31_HUMAN]] May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis.<ref>PMID:9396746</ref> <ref>PMID:10958671</ref> | |||
==About this Structure== | |||
[[4jzp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JZP OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023967155</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Guettou, F.]] | |||
[[Category: Low, C.]] | |||
[[Category: Maddi, K.]] | |||
[[Category: Moberg, P.]] | |||
[[Category: Nordlund, P.]] | |||
[[Category: Quistgaard, E M.]] | |||
[[Category: Apoptosis]] | |||
[[Category: Transport protein]] | |||
Revision as of 08:09, 29 September 2013
Crystal structure of BAP31 vDED at acidic pH
Template:ABSTRACT PUBMED 23967155
Disease
[BAP31_HUMAN] BCAP31 is deleted in the chromosome Xq28 deletion syndrome which involves BCAP31 and the and the promoter region of ABCD1.
Function
[BAP31_HUMAN] May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis.[1] [2]
About this Structure
4jzp is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Quistgaard EM, Low C, Moberg P, Guettou F, Maddi K, Nordlund P. Structural and Biophysical Characterization of the Cytoplasmic Domains of Human BAP29 and BAP31. PLoS One. 2013;8(8):e71111. doi: 10.1371/journal.pone.0071111. PMID:23967155 doi:10.1371/journal.pone.0071111
- ↑ Annaert WG, Becker B, Kistner U, Reth M, Jahn R. Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31. J Cell Biol. 1997 Dec 15;139(6):1397-410. PMID:9396746
- ↑ Nguyen M, Breckenridge DG, Ducret A, Shore GC. Caspase-resistant BAP31 inhibits fas-mediated apoptotic membrane fragmentation and release of cytochrome c from mitochondria. Mol Cell Biol. 2000 Sep;20(18):6731-40. PMID:10958671
