3mtl: Difference between revisions

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{{STRUCTURE_3mtl|  PDB=3mtl  |  SCENE=  }}
==Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804==
===Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804===
<StructureSection load='3mtl' size='340' side='right' caption='[[3mtl]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3mtl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MTL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MTL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FEF:(2Z,3E)-2,3-BIINDOLE-2,3(1H,1H)-DIONE+3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}'>FEF</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mtl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mtl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mtl RCSB], [http://www.ebi.ac.uk/pdbsum/3mtl PDBsum]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mt/3mtl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>


==Function==
==See Also==
[[http://www.uniprot.org/uniprot/CDK16_HUMAN CDK16_HUMAN]] Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).<ref>PMID:22796189</ref> <ref>PMID:22798068</ref> <ref>PMID:22184064</ref> 
*[[Cyclin-dependent kinase|Cyclin-dependent kinase]]
 
__TOC__
==About this Structure==
</StructureSection>
[[3mtl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MTL OCA].
 
==Reference==
<references group="xtra"/><references/>
[[Category: Cyclin-dependent kinase]]
[[Category: Cyclin-dependent kinase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Amos, A.]]
[[Category: Amos, A]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith, C H]]
[[Category: Ayinampudi, V.]]
[[Category: Ayinampudi, V]]
[[Category: Berridge, G.]]
[[Category: Berridge, G]]
[[Category: Bountra, C.]]
[[Category: Bountra, C]]
[[Category: Bullock, A.]]
[[Category: Bullock, A]]
[[Category: Burgess-Brown, N.]]
[[Category: Burgess-Brown, N]]
[[Category: Das, S.]]
[[Category: Das, S]]
[[Category: Delft, F von.]]
[[Category: Delft, F von]]
[[Category: Edwards, A.]]
[[Category: Edwards, A]]
[[Category: Fedorov, O.]]
[[Category: Fedorov, O]]
[[Category: Filippakopoulos, P.]]
[[Category: Filippakopoulos, P]]
[[Category: Keates, T.]]
[[Category: Keates, T]]
[[Category: Knapp, S.]]
[[Category: Knapp, S]]
[[Category: Krojer, T.]]
[[Category: Krojer, T]]
[[Category: Muniz, J.]]
[[Category: Muniz, J]]
[[Category: Phillips, C.]]
[[Category: Phillips, C]]
[[Category: Pike, A C.W.]]
[[Category: Pike, A C.W]]
[[Category: Rellos, P.]]
[[Category: Rellos, P]]
[[Category: Roos, A.]]
[[Category: Roos, A]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Structural genomic]]
[[Category: Savitsky, P.]]
[[Category: Savitsky, P]]
[[Category: Sharpe, T D.]]
[[Category: Sharpe, T D]]
[[Category: Thangaratnarajah, C.]]
[[Category: Thangaratnarajah, C]]
[[Category: Ugochukwu, E.]]
[[Category: Ugochukwu, E]]
[[Category: Vollmar, M.]]
[[Category: Vollmar, M]]
[[Category: Weigelt, J.]]
[[Category: Weigelt, J]]
[[Category: Yue, W.]]
[[Category: Yue, W]]
[[Category: Zhang, Y.]]
[[Category: Zhang, Y]]
[[Category: Indirubin]]
[[Category: Indirubin]]
[[Category: Kinase]]
[[Category: Kinase]]
[[Category: Pctaire1]]
[[Category: Pctaire1]]
[[Category: Sgc]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 17:54, 18 December 2014

Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804

3mtl, resolution 2.40Å

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