2ewb: Difference between revisions

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[[Image:2ewb.gif|left|200px]]<br /><applet load="2ewb" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2ewb.gif|left|200px]]
caption="2ewb, resolution 1.85&Aring;" />
 
'''The crystal structure of Bovine Lens Leucine Aminopeptidase in complex with zofenoprilat'''<br />
{{Structure
|PDB= 2ewb |SIZE=350|CAPTION= <scene name='initialview01'>2ewb</scene>, resolution 1.85&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=ZED:L-PROLINE,+1-[(2S)-3-MERCAPTO-2-METHYL-1-OXOPROPYL]-4-(PHENYLTHIO)-,+4S'>ZED</scene> and <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Leucyl_aminopeptidase Leucyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.1 3.4.11.1]
|GENE=
}}
 
'''The crystal structure of Bovine Lens Leucine Aminopeptidase in complex with zofenoprilat'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2EWB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=CO3:'>CO3</scene>, <scene name='pdbligand=ZED:'>ZED</scene> and <scene name='pdbligand=MPD:'>MPD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Leucyl_aminopeptidase Leucyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.1 3.4.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EWB OCA].  
2EWB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EWB OCA].  


==Reference==
==Reference==
Metal ion substitution in the catalytic site greatly affects the binding of sulfhydryl-containing compounds to leucyl aminopeptidase., Cappiello M, Alterio V, Amodeo P, Del Corso A, Scaloni A, Pedone C, Moschini R, De Donatis GM, De Simone G, Mura U, Biochemistry. 2006 Mar 14;45(10):3226-34. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16519517 16519517]
Metal ion substitution in the catalytic site greatly affects the binding of sulfhydryl-containing compounds to leucyl aminopeptidase., Cappiello M, Alterio V, Amodeo P, Del Corso A, Scaloni A, Pedone C, Moschini R, De Donatis GM, De Simone G, Mura U, Biochemistry. 2006 Mar 14;45(10):3226-34. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16519517 16519517]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Leucyl aminopeptidase]]
[[Category: Leucyl aminopeptidase]]
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[[Category: metallopeptidase]]
[[Category: metallopeptidase]]


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