2ewy: Difference between revisions

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[[Image:2ewy.gif|left|200px]]<br /><applet load="2ewy" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2ewy.gif|left|200px]]
caption="2ewy, resolution 3.10&Aring;" />
 
'''Crystal structure of human BACE2 in complex with a hydroxyethylenamine transition-state inhibitor'''<br />
{{Structure
|PDB= 2ewy |SIZE=350|CAPTION= <scene name='initialview01'>2ewy</scene>, resolution 3.10&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=DBO:N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHYLBENZYL)AMINO]PROPYL}DIBENZO[B,F]OXEPINE-10-CARBOXAMIDE'>DBO</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Memapsin_1 Memapsin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.45 3.4.23.45]
|GENE= BACE2, ASP21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of human BACE2 in complex with a hydroxyethylenamine transition-state inhibitor'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2EWY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=DBO:'>DBO</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Memapsin_1 Memapsin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.45 3.4.23.45] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EWY OCA].  
2EWY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EWY OCA].  


==Reference==
==Reference==
Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor., Ostermann N, Eder J, Eidhoff U, Zink F, Hassiepen U, Worpenberg S, Maibaum J, Simic O, Hommel U, Gerhartz B, J Mol Biol. 2006 Jan 13;355(2):249-61. Epub 2005 Nov 8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16305800 16305800]
Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor., Ostermann N, Eder J, Eidhoff U, Zink F, Hassiepen U, Worpenberg S, Maibaum J, Simic O, Hommel U, Gerhartz B, J Mol Biol. 2006 Jan 13;355(2):249-61. Epub 2005 Nov 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16305800 16305800]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Memapsin 1]]
[[Category: Memapsin 1]]
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[[Category: bace2]]
[[Category: bace2]]


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