4bis: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===JMJD2A COMPLEXED WITH 8-HYDROXYQUINOLINE-4-CARBOXYLIC ACID===

~~The entry 4bis is ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/KDM4A_HUMAN KDM4A_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref> Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref>

~~Authors~~: ~~CHOWDHURY, R~~.~~, Thinnes, C~~.~~, SCHOFIELD, C~~.J.

==About this Structure==

[[4bis]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIS OCA].

~~Description~~: ~~JMJD2A COMPLEXED WITH 8~~-~~HYDROXYQUINOLINE~~-~~4-CARBOXYLIC ACID~~

==Reference==

[[Category: Chowdhury, R.]]

[[Category: Schofield, C J.]]

[[Category: Thinnes, C.]]

[[Category: 2-oxoglutarate]]

[[Category: Chromatin regulator]]

[[Category: Dioxygenase]]

[[Category: Epigenetic and transcription regulation]]

[[Category: Facial triad]]

[[Category: Hydroxylation]]

[[Category: Metal binding protein]]

[[Category: Non-heme]]

[[Category: Oxidoreductase]]

[[Category: Oxygenase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4bis|  PDB=4bis  |  SCENE=  }}
+===JMJD2A COMPLEXED WITH 8-HYDROXYQUINOLINE-4-CARBOXYLIC ACID===
-The entry 4bis is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/KDM4A_HUMAN KDM4A_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref>   Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref>
-Authors: CHOWDHURY, R., Thinnes, C., SCHOFIELD, C.J.
+==About this Structure==
+[[4bis]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIS OCA].
-Description: JMJD2A COMPLEXED WITH 8-HYDROXYQUINOLINE-4-CARBOXYLIC ACID
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Chowdhury, R.]]
+[[Category: Schofield, C J.]]
+[[Category: Thinnes, C.]]
+[[Category: 2-oxoglutarate]]
+[[Category: Chromatin regulator]]
+[[Category: Dioxygenase]]
+[[Category: Epigenetic and transcription regulation]]
+[[Category: Facial triad]]
+[[Category: Hydroxylation]]
+[[Category: Metal binding protein]]
+[[Category: Non-heme]]
+[[Category: Oxidoreductase]]
+[[Category: Oxygenase]]