4jva: Difference between revisions
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{{STRUCTURE_4jva| PDB=4jva | SCENE= }} | |||
===Crystal Structure of RIIbeta(108-402) bound to HE33, a N6 di-propyl substituted cAMP analog=== | |||
{{ABSTRACT_PUBMED_23978166}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/KAP3_RAT KAP3_RAT]] Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. | |||
==About this Structure== | |||
[[4jva]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVA OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023978166</ref><references group="xtra"/><references/> | |||
[[Category: Rattus norvegicus]] | |||
[[Category: Brown, S H.J.]] | |||
[[Category: Cheng, C Y.]] | |||
[[Category: Cottam, H.]] | |||
[[Category: Saldanha, A S.]] | |||
[[Category: Sankaran, B.]] | |||
[[Category: Taylor, S S.]] | |||
[[Category: Wu, J.]] | |||
[[Category: Camp-dependent protein kinase]] | |||
[[Category: Cyclic nucleotide analog]] | |||
[[Category: Fluorescence anisotropy]] | |||
[[Category: Isoform selectivity]] | |||
[[Category: Transferase-transferase inhibitor complex]] | |||
Revision as of 04:11, 20 September 2013
Crystal Structure of RIIbeta(108-402) bound to HE33, a N6 di-propyl substituted cAMP analog
Template:ABSTRACT PUBMED 23978166
Function
[KAP3_RAT] Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
About this Structure
4jva is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
- Brown SH, Cheng CY, Saldanha SA, Wu J, Cottam HB, Sankaran B, Taylor SS. Implementing Fluorescence Anisotropy Screening and Crystallographic Analysis to Define PKA Isoform-Selective Activation by cAMP Analogs. ACS Chem Biol. 2013 Sep 10. PMID:23978166 doi:10.1021/cb400247t
