4k69: Difference between revisions
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{{STRUCTURE_4k69| PDB=4k69 | SCENE= }} | |||
===Crystal Structure of Human Chymase in Complex with Fragment Linked Benzimidazolone Inhibitor: (3S)-3-{3-[(6-bromo-2-oxo-2,3-dihydro-1H-indol-4-yl)methyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}hexanoic acid=== | |||
{{ABSTRACT_PUBMED_23659209}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CMA1_HUMAN CMA1_HUMAN]] Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. | |||
==About this Structure== | |||
[[4k69]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K69 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023659209</ref><references group="xtra"/><references/> | |||
[[Category: Chymase]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Collins, B K.]] | |||
[[Category: Padyana, A K.]] | |||
[[Category: Glycosylated]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Mast cell]] | |||
[[Category: Secreted]] | |||
[[Category: Serine protease]] | |||
Revision as of 13:22, 19 June 2013
Crystal Structure of Human Chymase in Complex with Fragment Linked Benzimidazolone Inhibitor: (3S)-3-{3-[(6-bromo-2-oxo-2,3-dihydro-1H-indol-4-yl)methyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}hexanoic acid
Template:ABSTRACT PUBMED 23659209
Function
[CMA1_HUMAN] Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
About this Structure
4k69 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Taylor SJ, Padyana AK, Abeywardane A, Liang S, Hao MH, De Lombaert S, Proudfoot JR, Farmer BS, Li X, Collins B, Albaugh DR, Martin L, Hill-Drzewi M, Pullen SS, Takahashi H. Discovery of Potent, Selective Chymase Inhibitors via Fragment Linking Strategies. J Med Chem. 2013 May 9. PMID:23659209 doi:10.1021/jm400138z
