2f2c: Difference between revisions

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[[Image:2f2c.gif|left|200px]]<br /><applet load="2f2c" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2f2c.gif|left|200px]]
caption="2f2c, resolution 2.80&Aring;" />
 
'''X-ray structure of human CDK6-Vcyclinwith the inhibitor aminopurvalanol'''<br />
{{Structure
|PDB= 2f2c |SIZE=350|CAPTION= <scene name='initialview01'>2f2c</scene>, resolution 2.80&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=AP9:(2S)-2-({6-[(3-AMINO-5-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL'>AP9</scene> and <scene name='pdbligand=DMS:DIMETHYL SULFOXIDE'>DMS</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1]
|GENE= 72, ECLF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10381 Saimiriine herpesvirus 2]), CDK6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''X-ray structure of human CDK6-Vcyclinwith the inhibitor aminopurvalanol'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2F2C is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Saimiriine_herpesvirus_2 Saimiriine herpesvirus 2] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=AP9:'>AP9</scene> and <scene name='pdbligand=DMS:'>DMS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2C OCA].  
2F2C is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Saimiriine_herpesvirus_2 Saimiriine herpesvirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2C OCA].  


==Reference==
==Reference==
Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition., Lu H, Schulze-Gahmen U, J Med Chem. 2006 Jun 29;49(13):3826-31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16789739 16789739]
Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition., Lu H, Schulze-Gahmen U, J Med Chem. 2006 Jun 29;49(13):3826-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16789739 16789739]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: small molecule inhibitor bound between n-terminal and c-terminal domain of kinase]]
[[Category: small molecule inhibitor bound between n-terminal and c-terminal domain of kinase]]


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