4k6e: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "4k6e" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4k6e| PDB=4k6e | SCENE= }} | |||
===Crystal structure of Saccharomyces cerevisiae Dcp2 Nudix domain in complex with Mg=== | |||
{{ABSTRACT_PUBMED_23911090}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DCP2_YEAST DCP2_YEAST]] Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.<ref>PMID:10508173</ref> <ref>PMID:11139489</ref> <ref>PMID:11741542</ref> <ref>PMID:12554866</ref> | |||
==About this Structure== | |||
[[4k6e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6E OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023911090</ref><references group="xtra"/><references/> | |||
[[Category: Saccharomyces cerevisiae s288c]] | |||
[[Category: Aglietti, R A.]] | |||
[[Category: Floor, S N.]] | |||
[[Category: Gross, J D.]] | |||
[[Category: Hydrolase]] | |||
[[Category: Mrna decapping]] | |||
[[Category: Nudix]] | |||
[[Category: Nudix hydrolase]] | |||
