4hrv: Difference between revisions
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==Crystal Structure of Lipoprotein GNA1162 from Neisseria meningitidis== | |||
=== | <StructureSection load='4hrv' size='340' side='right' caption='[[4hrv]], [[Resolution|resolution]] 1.89Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4hrv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HRV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HRV FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gna1162 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=487 Neisseria meningitidis])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hrv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hrv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hrv RCSB], [http://www.ebi.ac.uk/pdbsum/4hrv PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
GNA1162, a predicted lipoprotein from Neisseria meningitidis, is a potential candidate for a universal vaccine against meningococcal disease caused by N. meningitidis serogroup B. Here, the crystal structure of GNA1162 at 1.89 A resolution determined by single-wavelength anomalous dispersion (SAD) is reported. The structure of GNA1162 appears to be a dimer in the crystallographic asymmetric unit as well as in solution. The overall structure of the dimer indicates that each monomer inserts its C-terminal alpha5 helix into the hydrophobic groove of the other molecule. Moreover, the beta4 strands of each monomer lie antiparallel to each other and interact through multiple main-chain hydrogen bonds. Through structural comparisons and operon predictions, it is hypothesized that GNA1162 is part of a transport system and assists in transport and reassembly. The crystal structure of GNA1162 sheds light on its possible function and provides potentially valuable information for the design of a vaccine against meningococcal disease. | |||
Structure of Neisseria meningitidis lipoprotein GNA1162.,Cai X, Lu J, Wu Z, Yang C, Xu H, Lin Z, Shen Y Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Apr 1;69(Pt 4):362-8. doi:, 10.1107/S1744309113004417. Epub 2013 Mar 28. PMID:23545639<ref>PMID:23545639</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Neisseria meningitidis]] | [[Category: Neisseria meningitidis]] | ||
[[Category: Cai, X | [[Category: Cai, X]] | ||
[[Category: Lin, Z | [[Category: Lin, Z]] | ||
[[Category: Shen, Y | [[Category: Shen, Y]] | ||
[[Category: Duf799]] | [[Category: Duf799]] | ||
[[Category: Lipid binding protein]] | [[Category: Lipid binding protein]] | ||
Revision as of 12:29, 21 December 2014
Crystal Structure of Lipoprotein GNA1162 from Neisseria meningitidis
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