4ej1: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4ej1| PDB=4ej1 | SCENE= }} | {{STRUCTURE_4ej1| PDB=4ej1 | SCENE= }} | ||
===Binding of Nb113 camelid antibody fragment with the binary DHFR:folate complex=== | ===Binding of Nb113 camelid antibody fragment with the binary DHFR:folate complex=== | ||
{{ABSTRACT_PUBMED_23911607}} | |||
==Function== | ==Function== | ||
| Line 7: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
[[4ej1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJ1 OCA]. | [[4ej1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJ1 OCA]. | ||
==See Also== | |||
*[[Dihydrofolate reductase|Dihydrofolate reductase]] | |||
==Reference== | |||
<ref group="xtra">PMID:023911607</ref><references group="xtra"/><references/> | |||
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
[[Category: Escherichia coli k-12]] | [[Category: Escherichia coli k-12]] | ||
Revision as of 06:23, 14 August 2013
Binding of Nb113 camelid antibody fragment with the binary DHFR:folate complex
Template:ABSTRACT PUBMED 23911607
Function
[DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
About this Structure
4ej1 is a 4 chain structure with sequence from Escherichia coli k-12 and Lama glama. Full crystallographic information is available from OCA.
See Also
Reference
- Oyen D, Wechselberger R, Srinivasan V, Steyaert J, Barlow JN. Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli. Biochim Biophys Acta. 2013 Jul 31. pii: S1570-9639(13)00282-3. doi:, 10.1016/j.bbapap.2013.07.010. PMID:23911607 doi:10.1016/j.bbapap.2013.07.010
