2f7o: Difference between revisions

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[[Image:2f7o.gif|left|200px]]<br /><applet load="2f7o" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2f7o.gif|left|200px]]
caption="2f7o, resolution 1.430&Aring;" />
 
'''Golgi alpha-mannosidase II complex with mannostatin A'''<br />
{{Structure
|PDB= 2f7o |SIZE=350|CAPTION= <scene name='initialview01'>2f7o</scene>, resolution 1.430&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=MSN:(1R,2R,3R,4S,5R)-4-AMINO-5-(METHYLTHIO)CYCLOPENTANE-1,2,3-TRIOL'>MSN</scene> and <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_1,3-1,6-alpha-mannosidase Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.114 3.2.1.114]
|GENE= alpha-Man-II, GmII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])
}}
 
'''Golgi alpha-mannosidase II complex with mannostatin A'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2F7O is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=MSN:'>MSN</scene> and <scene name='pdbligand=MPD:'>MPD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_1,3-1,6-alpha-mannosidase Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.114 3.2.1.114] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F7O OCA].  
2F7O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F7O OCA].  


==Reference==
==Reference==
Structural basis of the inhibition of Golgi alpha-mannosidase II by mannostatin A and the role of the thiomethyl moiety in ligand-protein interactions., Kawatkar SP, Kuntz DA, Woods RJ, Rose DR, Boons GJ, J Am Chem Soc. 2006 Jun 28;128(25):8310-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16787095 16787095]
Structural basis of the inhibition of Golgi alpha-mannosidase II by mannostatin A and the role of the thiomethyl moiety in ligand-protein interactions., Kawatkar SP, Kuntz DA, Woods RJ, Rose DR, Boons GJ, J Am Chem Soc. 2006 Jun 28;128(25):8310-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16787095 16787095]
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase]]
[[Category: Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase]]
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[[Category: glycosyl hydrolase family 38]]
[[Category: glycosyl hydrolase family 38]]


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