2f9k: Difference between revisions

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[[Image:2f9k.gif|left|200px]]<br /><applet load="2f9k" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2f9k.gif|left|200px]]
caption="2f9k, resolution 2.060&Aring;" />
 
'''Crystal structure of human FPPS in complex with Zoledronate and Zn2+'''<br />
{{Structure
|PDB= 2f9k |SIZE=350|CAPTION= <scene name='initialview01'>2f9k</scene>, resolution 2.060&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> and <scene name='pdbligand=ZOL:ZOLEDRONIC ACID'>ZOL</scene>
|ACTIVITY=
|GENE= FDPS, FPS, KIAA1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of human FPPS in complex with Zoledronate and Zn2+'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2F9K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=PO4:'>PO4</scene> and <scene name='pdbligand=ZOL:'>ZOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F9K OCA].  
2F9K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F9K OCA].  


==Reference==
==Reference==
Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs., Rondeau JM, Bitsch F, Bourgier E, Geiser M, Hemmig R, Kroemer M, Lehmann S, Ramage P, Rieffel S, Strauss A, Green JR, Jahnke W, ChemMedChem. 2006 Feb;1(2):267-73. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16892359 16892359]
Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs., Rondeau JM, Bitsch F, Bourgier E, Geiser M, Hemmig R, Kroemer M, Lehmann S, Ramage P, Rieffel S, Strauss A, Green JR, Jahnke W, ChemMedChem. 2006 Feb;1(2):267-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16892359 16892359]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: mevalonate pathway; isoprene biosynthesis; cholesterol biosynthesis; bisphosphonate inhibitor]]
[[Category: mevalonate pathway; isoprene biosynthesis; cholesterol biosynthesis; bisphosphonate inhibitor]]


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