Lambda repressor: Difference between revisions

The <scene name='Bacteriophage_Lambda_Repressor_cI/Csr/2'>region connecting the NTD to the CTD</scene> consists of 38 amino acid residues (residues 93-131) and contains the CSR ([[2hnf]]).  The CSR is on a long loop (residues 106-126) which serves to stabilize the homodimer through interactions with the connecting region of the opposite monomer.  Cleavage occurs between Ala 111 and Gly 112 in the CSR.  The natural structural conformation of the repressor is such that the auto-cleavage active site does not contact the CSR.  During bacterial stress response, RecA binds to the repressor which induces a conformational change, bringing the CSR into contact with the auto-cleavage active site residues (Ndjonka et. al, 2006).