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SUV39h1 is part of a class of methytransferase that deals with the methylation of histone proteins in nucleosomes. It is one of the very first histone methyltransferase to be discovered. The methylation of histone proteins is an essential part of an area of genetics which deals with the modification of histone proteins called epigenomics. Epigenomics is the study of modifications of nucleosomes, which either inhibit or express gene transcription without changing the underlining DNA sequence. These changes are allowed because of the amino acid tails which extend out and away from the histone proteins, exposing itself to methylation. Methylation of histone protein is one of many ways that regulates gene expression. The regulation of gene expression is dependent on the state of the gene. A gene cannot be transcribed when the promoter of the gene is wrapped around the nucleosome, forming a heterochromatin state; thus, the gene is inhibited from being transcribed. Conversely, Methylation of the histone protein causes the winding around the nucleosomes, transforming a euchromatin state into a heterochromatin state. Of course, SUV39H1 alone does not methylate the histone proteins. SUV39H1 interacts with other proteins in order to efficiently methylate a histone protein (shown in Figure 1). Abnormal expression of genes, which is the result of down regulation or mutation of SUV39H1, results in a variety of diseases.

SUV39h1 is part of a class of methytransferase that deals with the methylation of histone proteins in nucleosomes. It is one of the very first histone methyltransferase to be discovered <ref>PMID:17320507</ref>. The methylation of histone proteins is an essential part of an area of genetics which deals with the modification of histone proteins called epigenomics. Epigenomics is the study of modifications of nucleosomes, which either inhibit or express gene transcription without changing the underlining DNA sequence. These changes are allowed because of the amino acid tails which extend out and away from the histone proteins, exposing itself to methylation. Methylation of histone protein is one of many ways that regulates gene expression. The regulation of gene expression is dependent on the state of the gene. A gene cannot be transcribed when the promoter of the gene is wrapped around the nucleosome, forming a heterochromatin state; thus, the gene is inhibited from being transcribed. Conversely, Methylation of the histone protein causes the winding around the nucleosomes, transforming a euchromatin state into a heterochromatin state. Of course, SUV39H1 alone does not methylate the histone proteins. SUV39H1 interacts with other proteins in order to efficiently methylate a histone protein (shown in Figure 1). Abnormal expression of genes, which is the result of down regulation or mutation of SUV39H1, results in a variety of diseases.

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Sandbox Reserved 592: Difference between revisions

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-SUV39h1 is part of a class of methytransferase that deals with the methylation of histone proteins in nucleosomes.  It is one of the very first histone methyltransferase to be discovered. The methylation of histone proteins is an essential part of an area of genetics which deals with the modification of histone proteins called epigenomics. Epigenomics is the study of modifications of nucleosomes, which either inhibit or express gene transcription without changing the underlining DNA sequence. These changes are allowed because of the amino acid tails which extend out and away from the histone proteins, exposing itself to methylation. Methylation of histone protein is one of many ways that regulates gene expression. The regulation of gene expression is dependent on the state of the gene. A gene cannot be transcribed when the promoter of the gene is wrapped around the nucleosome, forming a heterochromatin state; thus, the gene is inhibited from being transcribed. Conversely, Methylation of the histone protein causes the winding around the nucleosomes, transforming a euchromatin state into a heterochromatin state. Of course, SUV39H1 alone does not methylate the histone proteins. SUV39H1 interacts with other proteins in order to efficiently methylate a histone protein (shown in Figure 1). Abnormal expression of genes, which is the result of down regulation or mutation of SUV39H1, results in a variety of diseases.
+SUV39h1 is part of a class of methytransferase that deals with the methylation of histone proteins in nucleosomes.  It is one of the very first histone methyltransferase to be discovered <ref>PMID:17320507</ref>. The methylation of histone proteins is an essential part of an area of genetics which deals with the modification of histone proteins called epigenomics. Epigenomics is the study of modifications of nucleosomes, which either inhibit or express gene transcription without changing the underlining DNA sequence. These changes are allowed because of the amino acid tails which extend out and away from the histone proteins, exposing itself to methylation. Methylation of histone protein is one of many ways that regulates gene expression. The regulation of gene expression is dependent on the state of the gene. A gene cannot be transcribed when the promoter of the gene is wrapped around the nucleosome, forming a heterochromatin state; thus, the gene is inhibited from being transcribed. Conversely, Methylation of the histone protein causes the winding around the nucleosomes, transforming a euchromatin state into a heterochromatin state. Of course, SUV39H1 alone does not methylate the histone proteins. SUV39H1 interacts with other proteins in order to efficiently methylate a histone protein (shown in Figure 1). Abnormal expression of genes, which is the result of down regulation or mutation of SUV39H1, results in a variety of diseases.
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