2rt5: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Structural insights into the recruitment of SMRT by the co-repressor SHARP under phosphorylative regulation===

~~The entry 2rt5 is ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/MINT_HUMAN MINT_HUMAN]] May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.<ref>PMID:11331609</ref> <ref>PMID:12374742</ref> [[http://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN]] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.

~~Authors~~: ~~Mikami, S~~.~~, Kanaba, T~~.~~, Mishima, M~~.

==About this Structure==

[[2rt5]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RT5 OCA].

~~Description~~: ~~Structural insights into the recruitment of SMRT by the co-repressor SHARP under phosphorylative regulation~~

==Reference==

[[Category: Kanaba, T.]]

[[Category: Mikami, S.]]

[[Category: Mishima, M.]]

[[Category: Phosphorylation]]

[[Category: Sharp]]

[[Category: Smrt]]

[[Category: Spoc domain]]

[[Category: Transcription regulator]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_2rt5|  PDB=2rt5  |  SCENE=  }}
+===Structural insights into the recruitment of SMRT by the co-repressor SHARP under phosphorylative regulation===
+{{ABSTRACT_PUBMED_24268649}}
-The entry 2rt5 is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/MINT_HUMAN MINT_HUMAN]] May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.<ref>PMID:11331609</ref> <ref>PMID:12374742</ref>  [[http://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN]] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.
-Authors: Mikami, S., Kanaba, T., Mishima, M.
+==About this Structure==
+[[2rt5]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RT5 OCA].
-Description: Structural insights into the recruitment of SMRT by the co-repressor SHARP under phosphorylative regulation
+==Reference==
+<ref group="xtra">PMID:024268649</ref><references group="xtra"/><references/>
+[[Category: Kanaba, T.]]
+[[Category: Mikami, S.]]
+[[Category: Mishima, M.]]
+[[Category: Phosphorylation]]
+[[Category: Sharp]]
+[[Category: Smrt]]
+[[Category: Spoc domain]]
+[[Category: Transcription regulator]]