2ffy: Difference between revisions

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[[Image:2ffy.gif|left|200px]]<br /><applet load="2ffy" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2ffy.gif|left|200px]]
caption="2ffy, resolution 1.07&Aring;" />
 
'''AmpC beta-lactamase N289A mutant in complex with a boronic acid deacylation transition state analog compound SM3'''<br />
{{Structure
|PDB= 2ffy |SIZE=350|CAPTION= <scene name='initialview01'>2ffy</scene>, resolution 1.07&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene> and <scene name='pdbligand=SM3:(1R)-1-(2-THIENYLACETYLAMINO)-1-PHENYLMETHYLBORONIC ACID'>SM3</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]
|GENE= ampC, ampA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
}}
 
'''AmpC beta-lactamase N289A mutant in complex with a boronic acid deacylation transition state analog compound SM3'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2FFY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=K:'>K</scene> and <scene name='pdbligand=SM3:'>SM3</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFY OCA].  
2FFY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFY OCA].  


==Reference==
==Reference==
The deacylation mechanism of AmpC beta-lactamase at ultrahigh resolution., Chen Y, Minasov G, Roth TA, Prati F, Shoichet BK, J Am Chem Soc. 2006 Mar 8;128(9):2970-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16506777 16506777]
The deacylation mechanism of AmpC beta-lactamase at ultrahigh resolution., Chen Y, Minasov G, Roth TA, Prati F, Shoichet BK, J Am Chem Soc. 2006 Mar 8;128(9):2970-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16506777 16506777]
[[Category: Beta-lactamase]]
[[Category: Beta-lactamase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: ampc; beta-lactamase; deacylation; transition state; boronic acid]]
[[Category: ampc; beta-lactamase; deacylation; transition state; boronic acid]]


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