4ijf: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4ijf|  PDB=4ijf  |  SCENE=  }}
===Crystal structure of the Zaire ebolavirus VP35 interferon inhibitory domain K222A/R225A/K248A/K251A mutant===
{{ABSTRACT_PUBMED_24067086}}


The entry 4ijf is ON HOLD until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/VP35_EBOZM VP35_EBOZM]] Acsts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.<ref>PMID:9971816</ref> <ref>PMID:11027311</ref> <ref>PMID:12829834</ref> <ref>PMID:16495261</ref> <ref>PMID:17065211</ref>  


Authors: Binning, J.B., Wang, T., Leung, D.W., Xu, W., Borek, D., Amarasinghe, G.K.
==About this Structure==
[[4ijf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebola_virus_-_mayinga,_zaire,_1976 Ebola virus - mayinga, zaire, 1976]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJF OCA].  


Description: Crystal structure of the Zaire ebolavirus VP35 interferon inhibitory domain K222A/R225A/K248A/K251A mutant
==Reference==
<ref group="xtra">PMID:024067086</ref><references group="xtra"/><references/>
[[Category: Ebola virus - mayinga, zaire, 1976]]
[[Category: Amarasinghe, G K.]]
[[Category: Binning, J B.]]
[[Category: Borek, D.]]
[[Category: Leung, D W.]]
[[Category: Wang, T.]]
[[Category: Xu, W.]]
[[Category: Dsrna]]
[[Category: Ifn inhibition]]
[[Category: Interferon antagonism]]
[[Category: Polymerase cofactor]]
[[Category: Rna binding protein]]
[[Category: Viral protein]]
[[Category: Virus]]
Retrieved from "https://proteopedia.org/4ijf"