4je3: Difference between revisions
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{{STRUCTURE_4je3| PDB=4je3 | SCENE= }} | |||
===An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation=== | |||
{{ABSTRACT_PUBMED_24075991}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/IML3_YEAST IML3_YEAST]] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation.<ref>PMID:11361335</ref> <ref>PMID:15241623</ref> [[http://www.uniprot.org/uniprot/CHL4_YEAST CHL4_YEAST]] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation.<ref>PMID:9339342</ref> | |||
==About this Structure== | |||
[[4je3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JE3 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024075991</ref><references group="xtra"/><references/> | |||
[[Category: Saccharomyces cerevisiae]] | |||
[[Category: Harrison, S C.]] | |||
[[Category: Hinshaw, S M.]] | |||
[[Category: Beta sheet]] | |||
[[Category: Cell cycle]] | |||
[[Category: Chromosome segregation]] | |||
[[Category: Iml3-chl4 dimer]] | |||
[[Category: Kinetochore]] | |||
[[Category: Nucleus]] | |||
Revision as of 08:00, 16 October 2013
An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation
Template:ABSTRACT PUBMED 24075991
Function
[IML3_YEAST] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation.[1] [2] [CHL4_YEAST] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation.[3]
About this Structure
4je3 is a 2 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
- Hinshaw SM, Harrison SC. An Iml3-Chl4 Heterodimer Links the Core Centromere to Factors Required for Accurate Chromosome Segregation. Cell Rep. 2013 Sep 25. pii: S2211-1247(13)00477-4. doi:, 10.1016/j.celrep.2013.08.036. PMID:24075991 doi:https://dx.doi.org/10.1016/j.celrep.2013.08.036
- ↑ Ghosh SK, Poddar A, Hajra S, Sanyal K, Sinha P. The IML3/MCM19 gene of Saccharomyces cerevisiae is required for a kinetochore-related process during chromosome segregation. Mol Genet Genomics. 2001 Apr;265(2):249-57. PMID:11361335
- ↑ Ghosh SK, Sau S, Lahiri S, Lohia A, Sinha P. The Iml3 protein of the budding yeast is required for the prevention of precocious sister chromatid separation in meiosis I and for sister chromatid disjunction in meiosis II. Curr Genet. 2004 Aug;46(2):82-91. Epub 2004 Jul 6. PMID:15241623 doi:https://dx.doi.org/10.1007/s00294-004-0516-6
- ↑ Roy N, Poddar A, Lohia A, Sinha P. The mcm17 mutation of yeast shows a size-dependent segregational defect of a mini-chromosome. Curr Genet. 1997 Sep;32(3):182-9. PMID:9339342
