4jgc: Difference between revisions
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{{STRUCTURE_4jgc| PDB=4jgc | SCENE= }} | |||
===Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)=== | |||
{{ABSTRACT_PUBMED_23680598}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TDG_HUMAN TDG_HUMAN]] In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine. | |||
==About this Structure== | |||
[[4jgc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGC OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023680598</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Thymine-DNA glycosylase]] | |||
[[Category: Cheng, X.]] | |||
[[Category: Hashimoto, H.]] | |||
[[Category: Zhang, X.]] | |||
[[Category: 5-carboxylcytosine]] | |||
[[Category: Dna 5mc oxidation]] | |||
[[Category: Dna demethylation]] | |||
[[Category: Dna modification]] | |||
[[Category: Epigenetic regulation]] | |||
[[Category: Hydrolase-dna complex]] | |||
[[Category: Thymine dna glycosylase]] | |||
Revision as of 16:11, 19 June 2013
Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)
Template:ABSTRACT PUBMED 23680598
Function
[TDG_HUMAN] In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.
About this Structure
4jgc is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Hashimoto H, Zhang X, Cheng X. Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH. DNA Repair (Amst). 2013 May 13. pii: S1568-7864(13)00084-0. doi:, 10.1016/j.dnarep.2013.04.003. PMID:23680598 doi:10.1016/j.dnarep.2013.04.003
