4ka4: Difference between revisions
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{{STRUCTURE_4ka4| PDB=4ka4 | SCENE= }} | |||
===Crystal structure of a proteolytically defined Zbeta domain of human DAI (ZBP1, DLM-1)=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ZBP1_HUMAN ZBP1_HUMAN]] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity). | |||
==About this Structure== | |||
[[4ka4]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KA4 OCA]. | |||
[[Category: Homo sapiens]] | |||
[[Category: Athanasiadis, A.]] | |||
[[Category: Rosa, M de.]] | |||
[[Category: Sanctis, D De.]] | |||
[[Category: Dna binding protein-dna complex]] | |||
[[Category: Dna sensor]] | |||
[[Category: Whth]] | |||
[[Category: Z-dna binding]] | |||
Revision as of 07:34, 16 May 2013
Crystal structure of a proteolytically defined Zbeta domain of human DAI (ZBP1, DLM-1)
Function
[ZBP1_HUMAN] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).
About this Structure
4ka4 is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
