4kax: Difference between revisions
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{{STRUCTURE_4kax| PDB=4kax | SCENE= }} | |||
===Crystal structure of the Grp1 PH domain in complex with Arf6-GTP=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ARF6_HUMAN ARF6_HUMAN]] GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension.<ref>PMID:7589240</ref> <ref>PMID:14978216</ref> <ref>PMID:11266366</ref> [[http://www.uniprot.org/uniprot/CYH3_HUMAN CYH3_HUMAN]] Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF through replacement of GDP with GTP. | |||
==About this Structure== | |||
[[4kax]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KAX OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Berg, B van den.]] | |||
[[Category: Lambright, D G.]] | |||
[[Category: Malaby, A W.]] | |||
[[Category: Ph domain]] | |||
[[Category: Phosphoinositide]] | |||
[[Category: Protein binding-signaling protein complex]] | |||