2fhy: Difference between revisions

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[[Image:2fhy.gif|left|200px]]<br /><applet load="2fhy" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2fhy.gif|left|200px]]
caption="2fhy, resolution 2.95&Aring;" />
 
'''Structure of human liver FPBase complexed with a novel benzoxazole as allosteric inhibitor'''<br />
{{Structure
|PDB= 2fhy |SIZE=350|CAPTION= <scene name='initialview01'>2fhy</scene>, resolution 2.95&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=A37:2,5-DICHLORO-N-(5-CHLORO-1,3-BENZOXAZOL-2-YL)BENZENESULFONAMIDE'>A37</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11]
|GENE=
}}
 
'''Structure of human liver FPBase complexed with a novel benzoxazole as allosteric inhibitor'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2FHY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=A37:'>A37</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FHY OCA].  
2FHY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FHY OCA].  


==Reference==
==Reference==
Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode., von Geldern TW, Lai C, Gum RJ, Daly M, Sun C, Fry EH, Abad-Zapatero C, Bioorg Med Chem Lett. 2006 Apr 1;16(7):1811-5. Epub 2006 Jan 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16442285 16442285]
Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode., von Geldern TW, Lai C, Gum RJ, Daly M, Sun C, Fry EH, Abad-Zapatero C, Bioorg Med Chem Lett. 2006 Apr 1;16(7):1811-5. Epub 2006 Jan 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16442285 16442285]
[[Category: Fructose-bisphosphatase]]
[[Category: Fructose-bisphosphatase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: intersubunit allosteric inhibition of human fpbase]]
[[Category: intersubunit allosteric inhibition of human fpbase]]


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