2flr: Difference between revisions

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[[Image:2flr.gif|left|200px]]<br /><applet load="2flr" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2flr.gif|left|200px]]
caption="2flr, resolution 2.35&Aring;" />
 
'''Novel 5-Azaindole Factor VIIa Inhibitors'''<br />
{{Structure
|PDB= 2flr |SIZE=350|CAPTION= <scene name='initialview01'>2flr</scene>, resolution 2.35&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=7NH:[2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA'>7NH</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21]
|GENE= F7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), F3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Novel 5-Azaindole Factor VIIa Inhibitors'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2FLR is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=7NH:'>7NH</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLR OCA].  
2FLR is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLR OCA].  


==Reference==
==Reference==
Novel 5-azaindole factor VIIa inhibitors., Riggs JR, Hu H, Kolesnikov A, Leahy EM, Wesson KE, Shrader WD, Vijaykumar D, Wahl TA, Tong Z, Sprengeler PA, Green MJ, Yu C, Katz BA, Sanford E, Nguyen M, Cabuslay R, Young WB, Bioorg Med Chem Lett. 2006 Jun 15;16(12):3197-200. Epub 2006 Apr 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16621549 16621549]
Novel 5-azaindole factor VIIa inhibitors., Riggs JR, Hu H, Kolesnikov A, Leahy EM, Wesson KE, Shrader WD, Vijaykumar D, Wahl TA, Tong Z, Sprengeler PA, Green MJ, Yu C, Katz BA, Sanford E, Nguyen M, Cabuslay R, Young WB, Bioorg Med Chem Lett. 2006 Jun 15;16(12):3197-200. Epub 2006 Apr 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16621549 16621549]
[[Category: Coagulation factor VIIa]]
[[Category: Coagulation factor VIIa]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Yu, C.]]
[[Category: Yu, C.]]
[[Category: 7NH]]
[[Category: 7NH]]
[[Category: 5-azaindole inhibitors]]
[[Category: 5-azaindole inhibitor]]
[[Category: s1 site]]
[[Category: s1 site]]
[[Category: short hydrogen bond]]
[[Category: short hydrogen bond]]


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